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KMID : 0359919920110030260
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Korean Journal of Nephrology
1992 Volume.11 No. 3 p.260 ~ p.269
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L-carnitine in Maintenance Hemodialysis Clinical, Lipid and Biochemical Effects
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Abstract
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Previous studies have reported conflicting results of carnitine supplementation on plasma lipids, clinical and biochemical effects in patients with chronic renal failure We therefore performed a double-blind placebo controlled trial to evaluate
the
effects of posthemodialysis intravenous injection of L-carnitine in ESRD patients on maintenance hemodialysis.
The trial which lasted two months (baseline, 2 months treatment) was double blind placebo controlled and randomized. Thirty longterm hemodialysis patients, were given carnitine (n=15) or placebo (N=15), completed this study. In each group,
clinical
lipid and biochemical parameters during treatment were compared with baseline values. Fifteen patients received oup to 2 months of L-carnitine infusion (>50 kg; 1.5g, <50 kg;1g) and 15 received placebo infusion (0.9% normal saline).
@ES The results were as follows:
@EN 1) there were no significant changes observed in plasma triglyceride HDL-cholesterol or other lipoprotein parameters except from fatty acid in either the carnitine or placebo treated group, Free fatty acid decreased signifiantly in the
carnnitine
treated group (p<0.005).
2) Intradialytic hypotension and muscle cramp were reduced only in the carnitine treated group (p<0.05).
3) No significant change was observed in serum urea nitrogen, creatinine or inorganic phosphorus in the carmitine or placebo treated groups.
4) Mid-arm circumference and triceps skinfold thickness were measured in all patients. No significant changes in any of these variables were noticed in either carnitine or placebo treated group.
In conclusion, intravenous L-carnitine in emodialysis patients appear to be associated with decrease in dialytic symptoms, sense of well-being and free fatty acid, not associated with any major effects on other lipid profiles.
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KEYWORD
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